Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists
Key result
Chronic AT1R blockade with losartan in spontaneously hypertensive rats induced AT2R-mediated vasorelaxation and increased nitric oxide production in response to Angiotensin II.
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Losartan 30 mg/kg/day in drinking water for 8… vs Untreated SHR and WKY rats
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
Loading...
Member takes
Overview
Supports AT2R mechanisms in ARB effects in rats; hypothesis-generating and requires clinical confirmation.
Structured PICO
P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats used to investigate the effects of long-term treatment with losartan on AT2R-mediated response.
I
Intervention
Losartan 30 mg/kg/day in drinking water for 8 weeks
C
Comparator
Untreated SHR and WKY rats
O
Outcome
Vasomotor response (relaxation) to Angiotensin II in isolated thoracic aortassurrogate
Chronic AT1 receptor blockade with losartan in hypertensive rats unmasks an AT2 receptor-mediated vasorelaxation via nitric oxide production, contributing to its beneficial hemodynamic effects.
Cite This Study
Cosentino et al. (2005) studied Hypertension. Losartan vs. Untreated animals was evaluated on Ang II induced concentration-dependent relaxation and NO production. Chronic AT1R blockade with losartan in spontaneously hypertensive rats induced AT2R-mediated vasorelaxation and increased nitric oxide production in response to Angiotensin II.