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February 15, 2005CirculationOpen Access

In SHR, AT2R stimulation induced vasoconstriction, but treatments reducing arterial pressure (e.g., perindopril, high-dose hydralazine, or candesartan plus hydralazine) restored AT2R-mediated vasodilation and normalized AT2R expression.

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Why the study?

Does blood pressure reduction restore AT2R-mediated vasodilation in spontaneously hypertensive rats?

Population

Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Comparison

Antihypertensive treatments for 4 weeks in… vs Placebo

Design

Preclinical

Follow-up

4 weeks

Authors

DYDong Gil YouLLLaurent LoufraniCBCéline Baron

Discussion

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Overview

BP reduction may restore AT2R vasodilation in SHR; leaves open translation to human hypertension.

Structured PICO

Does blood pressure reduction restore AT2R-mediated vasodilation in spontaneously hypertensive rats?

P
Population
Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)
I
Intervention
Antihypertensive treatments for 4 weeks in drinking water: AT1R blockade (candesartan; 2 mg/kg per day), ACE inhibitor (perindopril; 3 mg/kg per day), nonselective vasodilator (hydralazine; 16 or 24 mg/kg per day), or candesartan plus hydralazine (16 mg/kg per day)
C
Comparator
Placebo
O
Outcome
Mean arterial pressure (MAP), AT2R expression, and AT2R function (vasodilation/vasoconstriction) in isolated mesenteric resistance arteriessurrogate

High blood pressure reduction by specific and nonspecific antihypertensive treatments restores AT2R expression and its vasodilator function in spontaneously hypertensive rats.

Cite This Study

You et al. (2005) studied this question.

synapsesocial.com/papers/6a7fa228313cf8ea533e87f3https://doi.org/10.1161/01.cir.0000156503.62815.48
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