Population
Isolated, preconstricted mesenteric arterial bed from 6-week-old and 24-week-old spontaneously hypertensive…
Comparison
Angiotensin II (10-300 nmol) administration vs Age-matched normotensive rats and young vs adult…
Design
Preclinical
Authors
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Reduced AT2 vasodilation in adult SHR despite receptor upregulation cautions against adult translation; leaves open endothelial dysfunction as a therapeutic target.
Angiotensin II induces an AT2 receptor-mediated vasodilator effect that is reduced in adult SHR despite enhanced AT2 receptor expression, likely due to endothelial dysfunction.
Ognibene et al. (2008) studied this question.
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