Population
6-week-old and 21-week-old spontaneously hypertensive rats and age-matched Wistar-Kyoto rats
Comparison
Angiotensin II and vasopressin stimulation of… vs Age-matched Wistar-Kyoto rats and comparison…
Design
Preclinical
Authors
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Augmented early Ang II reactivity attenuates with remodeling in SHR; leaves open translation to human hypertension stages.
In spontaneously hypertensive rats, the initially enhanced vascular reactivity to Ang II during early hypertension is attenuated as hypertension progresses and structural vascular changes become more severe.
Dierk Endemann (1999) studied this question.
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