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April 1, 1993HypertensionOpen Access

Enhanced renal angiotensin II subtype 1 receptor responses in the spontaneously hypertensive rat.

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Why the study?

Does intrarenal Angiotensin II infusion cause enhanced renal vasoconstriction in spontaneously hypertensive rats compared to Wistar-Kyoto control rats?

Population

Adult spontaneously hypertensive rats and Wistar-Kyoto control rats, maintained in a normotensive state from…

Comparison

Intrarenal Angiotensin II infusions and… vs Wistar-Kyoto control rats receiving the same…

Design

Preclinical

Authors

CKCurtis K. KostUniversity of South DakotaEJEdwin K. JacksonCross-Cutting Cardiology

Discussion

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Overview

Hypothesis-generating for AT1-mediated renal effects in genetic hypertension; human studies required before any clinical consideration.

Structured PICO

Does intrarenal Angiotensin II infusion cause enhanced renal vasoconstriction in spontaneously hypertensive rats compared to Wistar-Kyoto control rats?

P
Population
Adult (12- to 14-week-old) spontaneously hypertensive rats (SHR) and Wistar-Kyoto control rats, maintained in a normotensive state from 4 weeks of age with long-term captopril treatment (100 mg/kg per day)
I
Intervention
Intrarenal Angiotensin II infusions (with or without AT1 receptor antagonist DuP 753 or AT2 receptor antagonist PD 123177) and periarterial renal nerve stimulation
C
Comparator
Wistar-Kyoto control rats receiving the same interventions
O
Outcome
Changes in renal blood flow, glomerular filtration rate, and renal vascular resistancesurrogate

Spontaneously hypertensive rats exhibit a genetically determined, enhanced renal responsiveness to Angiotensin II that is mediated specifically by the AT1 receptor.

Cite This Study

Kost et al. (1993) studied this question.

synapsesocial.com/papers/6a855dd3beaf5c5b09108e59https://doi.org/10.1161/01.hyp.21.4.420
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin and thromboxane in genetically hypertensive rats: renal blood flow and receptor studies1991 · 48 citations
  2. 2Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats1990 · 92 citations
  3. 3Physiological and immunopathological consequences of active immunization of spontaneously hypertensive and normotensive rats against murine renin.1990 · 65 citations
  4. 4Prevention of hypertension and vascular changes by captopril treatment.1991 · 113 citations
  5. 5EFFECTS OF CHRONIC TREATMENT WITH CAPTOPRIL(SQ 14,225), AN ORALLY ACTIVE INHIBITOR OFANGIOTENSIN I-CONVERTING ENZYME, INSPONTANEOUSLY HYPERTENSIVE RATS1979 · 94 citations