September 1, 1996Clinical and Experimental Pharmacology and Physiology
Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: STRUCTURAL CHANGES IN THE RENAL VASCULATURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT: NO EFFECT OF ANGIOTENSIN II BLOCKADE
Why the study?
Does angiotensin II blockade prevent structural changes in the renal vasculature in the spontaneously hypertensive rat?
Population
Spontaneously hypertensive rat (SHR) model and normotensive Wistar-Kyoto (WKY) rats
Comparison
Angiotensin II blockade vs No blockade / WKY rats
Design
Preclinical
Authors
Discussion
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Overview
Pre-glomerular hypertrophy in SHR occurs independently of Ang II; hypothesis-generating for non-RAS mechanisms and warrants caution extrapolating to patients.
Structured PICO
Does angiotensin II blockade prevent structural changes in the renal vasculature in the spontaneously hypertensive rat?
P
Population
Spontaneously hypertensive rat (SHR) model and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
Angiotensin II blockade
C
Comparator
No blockade / WKY rats
O
Outcome
Structural changes in the renal vasculature (hypertrophy of pre-glomerular vessels, glomerular number and volume)surrogate
Pre-glomerular vascular hypertrophy in spontaneously hypertensive rats is independent of angiotensin II, suggesting other mechanisms initiate and maintain hypertension in this model.
Cite This Study
Kett et al. (1996) studied this question.