Why the study?
Does AT1 receptor blockade with losartan prevent renal damage and hypertension in spontaneously hypertensive rats compared to non-specific blood pressure lowering with hydralazine?
Population
4-week-old and 14-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) control rats
Comparison
Losartan or hydralazine by gavage for 10 weeks vs Untreated SHR and WKY rats
Design
Preclinical
Follow-up
10 weeks
Authors
Loading...
Hypothesis-generating for AT1-specific renal protection beyond BP lowering; leaves open translation to human hypertensive nephropathy.
Does AT1 receptor blockade with losartan prevent renal damage and hypertension in spontaneously hypertensive rats compared to non-specific blood pressure lowering with hydralazine?
In spontaneously hypertensive rats, renal injury is driven by an imbalance in AT1R and AT2R expression and is prevented by AT1R blockade (losartan) but not by non-specific blood pressure lowering (hydralazine).
Landgraf et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: