Key result
Young (4-week-old) spontaneously hypertensive rats had significantly increased proximal tubule AT1R mRNA expression compared to controls, which was reversed by 1-week treatment with L-DOPA or captopril (P<0.005).
Why the study?
Does treatment with L-DOPA or captopril reduce elevated proximal tubule AT1R expression in young spontaneously hypertensive rats?
Population
Young (4 wk) and adult (14 wk) spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats.
Comparison
L-DOPA or captopril administered for 1 week to… vs Untreated SHR and WKY rats.
Design
Preclinical
Follow-up
1 week
Authors
Loading...
Supports RAS involvement in early SHR hypertension; leaves open translational relevance to human salt-sensitive hypertension.
Does treatment with L-DOPA or captopril reduce elevated proximal tubule AT1R expression in young spontaneously hypertensive rats?
p-value: p=<0.005
Young spontaneously hypertensive rats exhibit increased renal proximal tubule AT1R expression before established hypertension, which is normalized by early treatment with captopril or L-DOPA, supporting the role of the renin-angiotensin system in hypertension development.
Cheng et al. (1998) studied Hypertension. L-DOPA or captopril vs. Untreated SHR and WKY rats was evaluated on Proximal tubule AT1R mRNA expression (p=<0.005). Young (4-week-old) spontaneously hypertensive rats had significantly increased proximal tubule AT1R mRNA expression compared to controls, which was reversed by 1-week treatment with L-DOPA or captopril (P<0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: