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January 1, 1998Journal of Vascular Research

Vasodilation Mediated by Angiotensin II Type 2 Receptor Is Impaired in Afferent Arterioles of Young Spontaneously Hypertensive Rats

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Population

Microdissected afferent arterioles from the superficial cortex of 4- to 5-week-old spontaneously…

Comparison

Angiotensin II perfusion in vitro, with or… vs WKY rats compared to SHR, and baseline vs…

Design

Preclinical

Authors

YEYoshimi EndoSAShuji ArimaHYHiraku Yaoita

Discussion

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Overview

Suggests AT2 impairment in early hypertensive renal vasoconstriction; hypothesis-generating and requires human confirmation before any clinical relevance.

Structured PICO

P
Population
Microdissected afferent arterioles from the superficial cortex of 4- to 5-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar Kyoto rats (WKY)
I
Intervention
Angiotensin II (10^-11 to 10^-8 M) perfusion in vitro, with or without AT2 receptor antagonist PD123319 or AT1 receptor blockade
C
Comparator
WKY rats (normotensive controls) compared to SHR, and baseline vs. antagonist treatment
O
Outcome
Change in luminal diameter of afferent arteriolessurrogate

Impaired AT2 receptor-mediated vasodilation contributes to the exaggerated vasoconstrictor action of Angiotensin II in the afferent arterioles of prehypertensive spontaneously hypertensive rats.

Cite This Study

Endo et al. (1998) studied this question.

synapsesocial.com/papers/6a718d37f44fa9f079df555fhttps://doi.org/10.1159/000025613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pressure-induced constriction of the afferent arteriole of spontaneously hypertensive rats.1992 · 44 citations
  2. 2Differential pressor and renal vascular reactivity to angiotensin II in spontaneously hypertensive and Wistar-Kyoto rats.1987 · 27 citations
  3. 3Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet.1997 · 103 citations
  4. 4AT<sub>2</sub>Receptor Stimulation Increases Aortic Cyclic GMP in SHRSP by a Kinin-Dependent Mechanism1998 · 395 citations
  5. 5The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.1996 · 313 citations