Why the study?
Does AT2 receptor activation induce renal vasodilatation and regulate blood pressure in preclinical models?
Population
Preclinical models including rabbit afferent arterioles, AT2 receptor-null mutant mice, and stroke-prone…
Comparison
Activation of Angiotensin II type 2 receptors vs AT1 receptor activation or wild-type controls
Design
Review
Authors
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Supports AT2 counter-regulation in renal vessels; leaves open clinical translation to hypertension or CKD therapies.
Does AT2 receptor activation induce renal vasodilatation and regulate blood pressure in preclinical models?
AT2 receptor activation mediates renal vasodilatation via EETs and counter-regulates AT1-mediated vasoconstriction, suggesting a mechanism for the renoprotective and antihypertensive effects of AT1 receptor antagonists.
Arima et al. (2000) studied this question.
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