Effects of AT 1 and AT 2 Angiotensin Receptor Antagonists in Angiotensin II-Infused Rats
Why the study?
Does AT1 or AT2 receptor antagonism prevent Angiotensin II-induced hypertension and cardiovascular growth in Wistar rats?
Population
Wistar rats infused with Angiotensin II (120 ng/kg/min subcutaneously by osmotic minipump)
Comparison
AT1 antagonist losartan or AT2 antagonist… vs Untreated rats and Angiotensin II-infused rats…
Design
Preclinical
Follow-up
21 days
Authors
Discussion
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Member takes
Implication
AT1 but not AT2 antagonism mitigates Ang II effects in rats; extends mechanistic insights but leaves open human translation.
Structured PICO
Does AT1 or AT2 receptor antagonism prevent Angiotensin II-induced hypertension and cardiovascular growth in Wistar rats?
P
Population
Wistar rats infused with Angiotensin II (120 ng/kg/min subcutaneously by osmotic minipump)
I
Intervention
AT1 antagonist losartan (10 mg/kg/d in drinking water) or AT2 antagonist PD123319 (30 mg/kg/d subcutaneously by osmotic minipump) for 21 days
C
Comparator
Untreated rats and Angiotensin II-infused rats without antagonists
O
Outcome
Tail-cuff systolic blood pressure, heart weight, aorta cross-section/body weight ratio, and small artery media characteristicssurrogate
In Angiotensin II-infused normotensive rats, AT1 receptor antagonism (losartan) but not AT2 receptor antagonism (PD123319) prevents hypertension and cardiovascular growth, supporting the primary role of AT1 receptors in mediating these effects.
Cite This Study
Li et al. (1998) studied this question.