June 1, 2001Journal of Hypertension
Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin II infusion
Key result
Angiotensin II infusion significantly increased AT2 receptor expression in the mesenteric artery of adult rats, an effect that was significantly reduced by the AT1 antagonist valsartan.
Population
Adult Sprague-Dawley rats
Comparison
Angiotensin II infusion for 14 days, with… vs Vehicle infusion
Design
Preclinical
Follow-up
14 days
Authors
Discussion
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Implication
No clinical implications from rat data; leaves open AT2 upregulation in human vascular remodeling.
Structured PICO
P
Population
Adult Sprague-Dawley rats infused with angiotensin II or vehicle for 14 days to assess AT2 receptor expression.
I
Intervention
Angiotensin II infusion (58.3 ng/min) for 14 days, with allocation to receive either valsartan (30 mg/kg per day) or PD123319 (830 ng/min)
C
Comparator
Vehicle infusion
O
Outcome
Gene and protein expression of the AT2 receptor in the mesenteric vasculaturesurrogate
Angiotensin II up-regulates AT2 receptor expression in the mesenteric arteries of adult rats via the AT1 receptor, which may play a role in vascular remodeling.
Cite This Study
Bonnet et al. (2001) studied this question. Angiotensin II infusion with or without valsartan or PD123319 vs. Vehicle was evaluated on Gene and protein expression of the AT2 receptor in the mesenteric vasculature. Angiotensin II infusion significantly increased AT2 receptor expression in the mesenteric artery of adult rats, an effect that was significantly reduced by the AT1 antagonist valsartan.