December 1, 2003Journal of the American Society of Nephrology

Increased Renal Vascular Endothelial Growth Factor and Angiopoietins by Angiotensin II Infusion Is Mediated by Both AT1 and AT2 Receptors

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Population

Male Sprague-Dawley rats

Comparison

Angiotensin II infusion for 14 days, with or… vs Vehicle infusion

Design

Preclinical

Follow-up

14 days

Authors

BRBishoy RizkallaDoctors Company (United States)JFJosephine M. ForbesTranslational Research Institute MCMark E. CooperUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Does not support changing ARB use in patients; leaves open dual AT1/AT2 blockade for glomerular disease in humans.

Structured PICO

Population

Male Sprague-Dawley rats

Intervention

Angiotensin II infusion (58.3 ng/min) for 14 days, with or without AT1 receptor antagonist valsartan (30 mg/kg per d) or AT2 receptor antagonist PD123319 (830 ng/min)

Comparator

Vehicle infusion

Outcome

Gene and protein expression of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2)surrogate

Both AT1 and AT2 receptors play important roles in mediating the proliferative and angiogenic actions of angiotensin II in the kidney.

Cite This Study

Rizkalla et al. (2003) studied this question.

synapsesocial.com/papers/6a7162e8ac440176ef2a1061 https://doi.org/10.1097/01.asn.0000099374.58607.c9

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Increased Renal Vascular Endothelial Growth Factor and Angiopoietins by Angiotensin II Infusion Is Mediated by Both AT1 and AT2 Receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased Renal Vascular Endothelial Growth Factor and Angiopoietins by Angiotensin II Infusion Is Mediated by Both AT1 and AT2 Receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider