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July 29, 2003Circulation ResearchOpen Access

Angiotensin II Type 2 Receptor Inhibits Vascular Endothelial Growth Factor–Induced Migration and In Vitro Tube Formation of Human Endothelial Cells

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Population

Human endothelial cells

Design

Preclinical

Authors

RBRalf A. BenndorfInstitute of PharmacologyRBRainer H. BögerVascular MedicineSESüleyman ErgünUniversity of Würzburg

Discussion

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Implication

These in vitro data should not change practice; leaves open AT2 receptor effects on angiogenesis in vivo.

Structured PICO

P
Population
Human endothelial cells (EA.hy926 cells, human coronary artery [HCA] and human dermal microvascular [HDM] endothelial cells)
I
Intervention
Angiotensin II (Ang II), AT2 receptor antagonist PD123,319, AT1 receptor antagonist losartan, AT2 receptor agonist CGP-42112A, and pertussis toxin (PTX)
O
Outcome
VEGF-induced endothelial cell migration and in vitro tube formationsurrogate

Angiotensin II inhibits VEGF-induced endothelial cell migration and tube formation via AT2 receptor stimulation, providing a mechanistic explanation for its antiangiogenic properties.

Cite This Study

Benndorf et al. (2003) studied this question.

synapsesocial.com/papers/6a71a10e53da1ffdb507c1dchttps://doi.org/10.1161/01.res.0000088358.99466.04
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Also Consider

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  2. 2Physiological and Pathophysiological Functions of the AT<sub>2</sub>Subtype Receptor of Angiotensin II2001 · 115 citations
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