Why the study?
Does Angiotensin II regulate in vivo angiogenesis through its AT1 and AT2 receptors in mice?
Population
Mice with normal ANG II levels, elevated ANG II levels, or AT2 receptor-deficient mice
Comparison
Enalapril, losartan, or genetic modifications vs Mice with normal ANG II levels or untreated…
Design
Preclinical
Authors
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No immediate clinical implications for ACEi/ARB use; extends preclinical evidence on AT1/AT2 balance in murine angiogenesis.
Does Angiotensin II regulate in vivo angiogenesis through its AT1 and AT2 receptors in mice?
Angiotensin II acts as a humoral regulator of peripheral angiogenesis, with the AT1 receptor mediating inhibition and the AT2 receptor mediating stimulation.
Walther et al. (2003) studied this question.
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