Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2002AJP Cell Physiology

Angiotensin II AT2 receptor inhibits smooth muscle cell migration via fibronectin cell production and binding

View Full Paper
Ask AI
Bookmark
Share

Population

Vascular smooth muscle cell line expressing the angiotensin II AT2 receptor and control cells

Comparison

Angiotensin II treatment in the presence of a… vs Control cells treated with Angiotensin II, or…

Design

Preclinical

Authors

CCCatherine ChassagneCentre Léon BérardCAC. AdamyInsermPRPhilippe RatajczakOrange (France)

Discussion

Loading...

Member takes

Implication

AT2R activation may limit SMC migration in vascular disease; extends mechanistic data but leaves open in vivo relevance and clinical translation.

Structured PICO

P
Population
Vascular smooth muscle cell (SMC) line expressing the angiotensin II AT2 receptor (SMC-vAT2) and control cells (SMC-v)
I
Intervention
Angiotensin II treatment in the presence of a saturating concentration of losartan (to inactivate the AT1R subtype)
C
Comparator
Control cells (SMC-v) treated with Angiotensin II, or basal conditions
O
Outcome
Cell migrationsurrogate

Activation of the angiotensin II AT2 receptor inhibits vascular smooth muscle cell migration by increasing cellular fibronectin synthesis and binding.

Cite This Study

Chassagne et al. (2002) studied this question.

synapsesocial.com/papers/6a7c16eff2ff589f13c628c5https://doi.org/10.1152/ajpcell.00318.2001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.1993 · 771 citations
  2. 2Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells.1994 · 129 citations
  3. 3FIBRONECTIN AND ITS RECEPTORS1988 · 1,343 citations
  4. 4Signalling mechanisms in the regulation of vascular cell migration1995 · 114 citations
  5. 5Introduction1993 · 47 citations