Key result
Functional AT(2) receptors are expressed in the fetal aorta and mediate reduced force development, but do not significantly contribute to the regulation of smooth muscle cell differentiation.
Population
Fetal mice (wild-type, heterozygous, and homozygous AT2R knockout)
Comparison
AT2R knockout and/or selective AT2R antagonist… vs Wild-type mice or untreated controls
Design
Preclinical
Authors
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Animal data on fetal AT2R force modulation require human validation; leaves open its role in smooth muscle differentiation.
Functional AT2R is expressed in the fetal aorta and mediates reduced force development, but does not significantly regulate smooth muscle cell differentiation.
Perlegas et al. (2004) studied Fetal vascular development. AT(2)R knockout and PD-123319 treatment vs. Wild-type mice / untreated was evaluated on Smooth muscle cell growth, contractility, and differentiation. Functional AT(2) receptors are expressed in the fetal aorta and mediate reduced force development, but do not significantly contribute to the regulation of smooth muscle cell differentiation.
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