November 20, 2001Circulation

Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT2Receptor

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Population

Mice lacking the angiotensin II AT2 receptor (AT2-KO mice) and wild-type control mice (WT)

Comparison

Deletion of the angiotensin II AT2 receptor… vs Wild-type control mice (WT)

Design

Preclinical

Follow-up

8 weeks (for ACE inhibitor treatment)

Authors

MBMarc BredeTechnical University of Munich KHKerstin HadamekUniversity of Würzburg LMLorenz MeinelUniversity of Würzburg

Discussion

Member takes

Implication

Vascular AT2 receptors may inhibit hypertrophy; leaves open translation from mouse models to human therapy.

Structured PICO

Population

Mice lacking the angiotensin II AT2 receptor (AT2-KO mice) and wild-type control mice (WT)

Intervention

Deletion of the angiotensin II AT2 receptor gene; subset treated with an ACE inhibitor for 8 weeks

Comparator

Wild-type control mice (WT)

Outcome

Cardiovascular functional and structural alterations (in vivo pressure responses, cardiac contractility, vascular reactivity, arterial morphometry, and Phospho-P70S6 kinase levels)surrogate

Vascular AT2 receptors play a crucial role in regulating vascular structure and function by inhibiting hypertrophic signaling via P70S6 kinase.

Cite This Study

Brede et al. (2001) studied this question.

synapsesocial.com/papers/6a7fa228313cf8ea533e87f6 https://doi.org/10.1161/hc4601.099401

View Full Paper

Ask AI

Bookmark

Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT2Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT2Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider