Population
Rat vascular smooth muscle cells engineered to express the type 2 angiotensin II receptor in a…
Comparison
Induction of AT2R by doxycycline addition, with… vs Untransfected VSMCs and stable transfectants…
Design
Preclinical
Follow-up
48 hours
Authors
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AT2R-mediated MMP-2 downregulation may limit restenosis; leaves open translation beyond rat VSMC models.
Conditional expression of the AT2 receptor in rat vascular smooth muscle cells downregulates Ang II-induced MMP-2 expression, suggesting a potential mechanism to control restenosis.
He (2009) studied this question.
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