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September 1, 2015ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)

Role of α1D‐adrenoceptors in vascular wall hypertrophy during angiotensinII‐induced hypertension

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Why the study?

Does BMY 7378 (α1D-AR antagonist) prevent vascular hypertrophy in Ang II-induced hypertension in male Wistar rats?

Population

Male Wistar rats (3 months-old)

Comparison

Continuous angiotensin II infusion via… vs Control rats

Design

Preclinical

Follow-up

2 or 4 weeks

Authors

IGItzell A. Gallardo‐OrtízAutonomous University of TlaxcalaSRSandra Rodríguez‐HernándezAutonomous University of TlaxcalaJLJuan Javier López-GuerreroInstituto Politécnico Nacional

Discussion

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Implication

α1D-AR blockade separates aortic hypertrophy from hypertension in Ang II rats; hypothesis-generating for human translation.

Structured PICO

Does BMY 7378 (α1D-AR antagonist) prevent vascular hypertrophy in Ang II-induced hypertension in male Wistar rats?

P
Population
Male Wistar rats (3 months-old)
I
Intervention
Continuous angiotensin II (Ang II) infusion (200 ng kg-1 min-1) via subcutaneous Alzet minipumps, with or without losartan (AT1R antagonist) or BMY 7378 (selective α1D-AR antagonist)
C
Comparator
Control rats
O
Outcome
Arterial blood pressure, vascular hypertrophy, and α1-adrenoceptors expressionsurrogate

Angiotensin II induces aortic hypertrophy via an α1D-adrenoceptor-mediated process that is independent of blood pressure elevation.

Cite This Study

Gallardo‐Ortíz et al. (2015) studied this question.

synapsesocial.com/papers/6a83d57bf4298de60b3c32dbhttps://doi.org/10.1111/aap.12035

Topics

Hypertension management
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Also Consider

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  1. 1The angiotensin AT2 receptor in left ventricular hypertrophy2010 · 43 citations
  2. 2Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus2015 · 17 citations
  3. 3Captopril therapy decreases both expression and function of α 1D ‐adrenoceptors in pre‐ hypertensive rat aorta2005 · 19 citations
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  5. 5Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats1998 · 21 citations