What question did this study set out to answer?

To determine whether arterial wall hypertrophy and PDGF-A expression in one-kidney, one-clip (1K1C) renal hypertension are driven by angiotensin II signaling through the AT1 receptor or by elevated blood pressure.

February 1, 2000AJP Heart and Circulatory PhysiologyOpen Access

AT₁receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does losartan reduce arterial wall hypertrophy or PDGF-A expression in rats with one-kidney, one-clip hypertension?

Population

Experimental (one-kidney, one-clip [1K1C] hypertension) and sham-operated rats

Comparison

Losartan (20 mg/kg/day) for 14 days vs Tap water for 14 days

Design

Preclinical

Follow-up

14 days

Authors

SPSheri B. ParkerDominion University College ADAnca D. DobrianEastern Virginia Medical School SWSuzanne S. WadeEastern Virginia Medical School

Discussion

Member takes

Implication

Losartan ineffective against vascular hypertrophy in 1K1C rats; leaves open AT1-independent remodeling pathways for further study.

Key Points

To determine whether arterial wall hypertrophy and PDGF-A expression in one-kidney, one-clip (1K1C) renal hypertension are driven by angiotensin II signaling through the AT1 receptor or by elevated blood pressure.
One-kidney, one-clip (1K1C) hypertensive and sham-operated control rats were treated with losartan (20 mg/kg/day) or tap water for 14 days.
Harvested the thoracic aorta, carotid, small mesenteric, and external spermatic arteries to perform stereological morphometry, BrdU immunohistochemistry, and in situ hybridization for PDGF-A mRNA and protein.
Mean arterial pressure remained elevated in 1K1C rats, and losartan failed to reduce the increased cross-sectional areas of the thoracic aorta, carotid, and small mesenteric arteries.
PDGF-A mRNA and medial protein expression increased markedly in 1K1C arteries compared with controls and were not suppressed by losartan treatment.
External spermatic artery diameter and cremaster microvascular density decreased in 1K1C rats, whereas BrdU-positive nuclei counts showed no significant differences between 1K1C and control arteries.

Structured PICO

Does losartan reduce arterial wall hypertrophy or PDGF-A expression in rats with one-kidney, one-clip hypertension?

Population

Experimental (one-kidney, one-clip [1K1C] hypertension) and sham-operated rats

Intervention

Losartan (20 mg/kg/day) for 14 days

Comparator

Tap water for 14 days

Outcome

Arterial wall hypertrophy (cross-sectional areas of thoracic, carotid, and small mesenteric artery) and PDGF-A expression (mRNA and protein)surrogate

AT1 receptor inhibition with losartan does not prevent vascular wall hypertrophy or PDGF-A expression in a rat model of renal hypertension, suggesting these effects are not dependent on AT1 receptor-mediated ANG II signaling.

Cite This Study

Parker et al. (2000) studied this question.

synapsesocial.com/papers/6a6f9bd85d37378ac1dcab33 https://doi.org/10.1152/ajpheart.2000.278.2.h613

View Full Paper

Ask AI

Bookmark

AT₁receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

AT₁receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider