Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1997Journal of Cardiovascular Pharmacology

Effect of AT1 Angiotensin-Receptor Blockade on Structure and Function of Small Arteries in SHR

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does losartan reduce blood pressure and induce regression of cardiovascular hypertrophy and endothelial dysfunction in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) control rats

Comparison

Losartan at low or high oral dose for 12 weeks vs Untreated SHRs and WKY rats

Design

Preclinical

Follow-up

12 weeks

Authors

JLJin-S. LiMedical Council of CanadaASAli Mohammad SharifiIran University of Medical SciencesESErnesto L. SchiffrinMedical Council of Canada

Discussion

Loading...

Member takes

Overview

Does not alter clinical hypertension management; leaves open translation of losartan effects on remodeling to humans.

Key Points

  • This research aims to evaluate the effects of AT1 angiotensin-receptor blockade on small arteries in spontaneously hypertensive rats (SHRs).
  • Spontaneously hypertensive rats were treated with losartan at low (20 mg/kg/day) and high (60 mg/kg/day) doses for 12 weeks.
  • Blood pressure and arterial structure/function were assessed through various methods including isometric wire myography and pressurized artery analysis.
  • Comparisons were made between treated SHRs and control Wistar-Kyoto (WKY) rats.
  • Blood pressure decreased significantly in SHRs treated with losartan, from 210 +/- 2 mm Hg to 181 +/- 1 mm Hg (low dose) and 156 +/- 4 mm Hg (high dose) (p < 0.01).
  • Cardiac and aortic hypertrophy were reduced in a dose-dependent manner, with enhancements in endothelium-dependent relaxation.
  • Losartan improved arterial structure, reducing media thickness and mediato-lumen ratio in small arteries compared to untreated SHRs.

Structured PICO

Does losartan reduce blood pressure and induce regression of cardiovascular hypertrophy and endothelial dysfunction in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) control rats
I
Intervention
Losartan (AT1 angiotensin-receptor antagonist) at low (20 mg/kg/day) or high (60 mg/kg/day) oral dose for 12 weeks
C
Comparator
Untreated SHRs and WKY rats
O
Outcome
Blood pressure, cardiac and aortic hypertrophy, and structure/function of small arteries (media thickness, media-to-lumen ratio, endothelial function)surrogate

Treatment with the selective angiotensin II receptor antagonist losartan induces regression of cardiovascular hypertrophy and endothelial dysfunction in genetic hypertension in rats.

Cite This Study

Li et al. (1997) studied this question.

synapsesocial.com/papers/6a70c838f44fa9f079de7cc5https://doi.org/10.1097/00005344-199707000-00011
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparison of the effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on the structural changes associated with hypertension in rat small arteries1995 · 39 citations
  2. 2Angiotensin II Receptor Antagonist Losartan Has Persistent Effects on Blood Pressure in the Young Spontaneously Hypertensive Rat: Lack of Relation to Vascular Structure2008 · 111 citations
  3. 3Prevention of hypertension and vascular changes by captopril treatment.1991 · 113 citations
  4. 4No persistent effect of angiotensin converting enzyme inhibitor treatment in Milan hypertensive rats despite regression of vascular structure1991 · 37 citations
  5. 5Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.1994 · 290 citations