Key result
Losartan and captopril given for 10 weeks prevented hypertension development and significantly reduced mesenteric resistance artery media/lumen ratio (P<0.001) in spontaneously hypertensive rats.
Why the study?
Does losartan or captopril prevent the development of hypertension and alter vascular structure in young spontaneously hypertensive rats?
Does losartan or captopril prevent the development of hypertension and alter vascular structure in young spontaneously hypertensive rats?
Absolute Event Rate: 5.3% vs 7.7%
p-value: p=<0.001
Losartan and captopril effectively prevent the development of hypertension in young spontaneously hypertensive rats, but their ability to affect blood pressure without altering vascular structure after 4 weeks suggests vascular structure is a poor predictor of long-term hypertensive levels.
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Supports early RAS blockade in genetic hypertension models; leaves open whether vascular remodeling predicts long-term BP or translates to humans.
Morton et al. (2008) studied Hypertension. Losartan vs. Captopril (100 mg/kg/day) and control was evaluated on Mesenteric resistance artery media/lumen (m1/l1) ratio (p=<0.001). Losartan and captopril given for 10 weeks prevented hypertension development and significantly reduced mesenteric resistance artery media/lumen ratio (P<0.001) in spontaneously hypertensive rats.
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