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September 1, 1996Hypertension

Cardiac and Vascular Effects of Long-term Losartan Treatment in Stroke-Prone Spontaneously Hypertensive Rats

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Why the study?

Does long-term losartan treatment improve cardiac function and metabolism in stroke-prone spontaneously hypertensive rats?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP)

Design

Preclinical

Follow-up

up to 20 weeks of age

Authors

PGPeter GohlkeShanghai Medical College of Fudan UniversityWLWolfgang LinzOntario Brain InstituteBSBernward A. SchölkensGoethe University Frankfurt

Discussion

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Implication

Rat model benefits do not inform practice; hypothesis-generating for losartan effects in hypertension.

Structured PICO

Does long-term losartan treatment improve cardiac function and metabolism in stroke-prone spontaneously hypertensive rats?

P
Population
Stroke-prone spontaneously hypertensive rats (SHRSP)
I
Intervention
Losartan 30 mg/kg per day orally, treated prenatally and subsequently up to the age of 20 weeks
O
Outcome
Functional and biochemical parameters of the heart and cGMP content in the aortasurrogate

Long-term losartan treatment prevents hypertension and left ventricular hypertrophy while improving cardiac function and metabolism in a rat model of spontaneous hypertension.

Cite This Study

Gohlke et al. (1996) studied this question.

synapsesocial.com/papers/6a7de06c603f5e16dd33abe6https://doi.org/10.1161/01.hyp.28.3.397
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Losartan on Angiotensin and Bradykinin Peptides and Angiotensin-Converting Enzyme1995 · 146 citations
  2. 2Angiotensin II Receptor Subtypes: Selective Antagonists and Functional Correlates1994 · 94 citations
  3. 3Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy.1993 · 284 citations
  4. 4Decreased responsiveness of the aortae of hypertensive rats to acetylcholine, histamine and noradrenaline1987 · 46 citations
  5. 5The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.1995 · 915 citations