Why the study?
Does losartan improve the structural and functional characteristics of the middle cerebral artery in stroke-prone spontaneously hypertensive rats?
Population
Young salt-loaded stroke-prone spontaneously hypertensive rats and age-matched Wistar-Kyoto rats
Comparison
Losartan 1 mg/kg or 10 mg/kg per day, from 5 to… vs Control SHR-SP and age-matched WKY rats
Design
Preclinical, randomly selected
Follow-up
from 5 to 20 weeks of age
Authors
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May support cerebrovascular protection in hypertensive rat models; leaves open translation to human stroke prevention.
Does losartan improve the structural and functional characteristics of the middle cerebral artery in stroke-prone spontaneously hypertensive rats?
In stroke-prone spontaneously hypertensive rats, long-term losartan administration prevents stroke and improves cerebral artery smooth muscle and endothelial cell functions.
Vacher et al. (1996) studied this question.
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