What does this research mean for the field?

Angiotensin II receptor blockade with losartan markedly reduces hypertension, prevents end-organ damage, and increases survival in chronically salt-loaded stroke-prone spontaneously hypertensive rats. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the protective effects of angiotensin II receptor blockade using losartan against hypertension and end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats.

January 1, 1993Journal of Hypertension

Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade

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Why the study?

Does oral losartan reduce hypertension and end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats?

Population

181 male stroke-prone spontaneously hypertensive rats (SHRSP) fed a 4% sodium diet from 6 to 18 weeks of age

Comparison

Losartan 30 mg/kg per day orally vs Untreated controls

Design

Preclinical

Follow-up

12 weeks (from 6 to 18 weeks of age)

Authors

MCMaria Jose F. CamargoCornell University NLNicola von LutterottiDuPont (United States)WCWallace G. CampbellNew York State Department of Health

Discussion

Member takes

Implication

Losartan benefits this rat model of malignant hypertension; leaves open translation to human therapy pending clinical trials.

Key Points

To evaluate the protective effects of angiotensin II receptor blockade using losartan against hypertension and end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats.
Studied 181 male stroke-prone spontaneously hypertensive rats fed a 4% sodium diet from 6 to 18 weeks of age.
Administered oral losartan at 30 mg/kg per day to 78 rats, comparing them with 103 untreated control rats.
Monitored blood pressure, plasma renin activity, renal function markers, and end-organ pathology throughout the transition to malignant hypertension.
Losartan completely prevented blood pressure increases during the first 4 weeks, and maintained significantly lower blood pressure than untreated controls at every subsequent time point.
Losartan preserved renal function by blunting glomerular filtration rate decline, controlling proteinuria, and delaying or preventing malignant nephrosclerosis.
Treatment significantly increased overall survival and completely prevented cerebrovascular infarcts compared to control animals.

Structured PICO

Does oral losartan reduce hypertension and end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats?

Population

181 male stroke-prone spontaneously hypertensive rats (SHRSP) fed a 4% sodium diet from 6 to 18 weeks of age

Intervention

Losartan 30 mg/kg per day orally

Comparator

Untreated controls

Outcome

Blood pressure, plasma renin activity (PRA), renal function and end-organ damagesurrogate

Angiotensin II receptor blockade with losartan markedly reduces hypertension and prevents end-organ damage, including cerebrovascular infarcts, in a rat model of malignant hypertension.

Cite This Study

Camargo et al. (1993) studied this question.

synapsesocial.com/papers/6a1925fec27e07dcc0d94dee https://doi.org/10.1097/00004872-199301000-00006

Topics

Hypertension management

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Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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