Why the study?
Does losartan protect against vascular remodeling and oxidative stress compared to atenolol in salt-loaded spontaneously hypertensive rats?
Population
3-month-old spontaneously hypertensive rats and Wistar-Kyoto control rats, n=50 total
Comparison
Losartan 30 mg/kg/day added to 1.5% NaCl water… vs Atenolol 50 mg/kg/day added to 1.5% NaCl water…
Design
Preclinical
Follow-up
5 months
Authors
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Losartan may confer vascular benefits beyond BP reduction in hypertensive models; leaves open translation to human outcomes.
Does losartan protect against vascular remodeling and oxidative stress compared to atenolol in salt-loaded spontaneously hypertensive rats?
In a salt-sensitive genetic hypertension rat model, AT1-receptor blockade with losartan provides vascular protection and reduces oxidative stress beyond its blood pressure-lowering effects.
Cavanagh et al. (2010) studied this question.
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