February 23, 2011Journal of HypertensionOpen Access

Salt-induced renal injury in SHRs is mediated by AT1 receptor activation

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Why the study?

Does losartan prevent salt-induced renal injury in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHRs)

Comparison

High-salt diet with or without losartan vs Normal-salt diet with or without losartan

Design

Preclinical

Follow-up

4 weeks

Authors

DSDinko SušićOchsner Medical Center EFEdward D. FröhlichGeneral Cardiology HKHiroyuki KoboriGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Losartan may confer BP-independent renal protection in salt-loaded hypertensive rats; hypothesis-generating for human CKD but should not change practice.

Structured PICO

Does losartan prevent salt-induced renal injury in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHRs)

Intervention

High-salt (8%) diet with or without losartan (30 mg/kg per day)

Comparator

Normal-salt diet with or without losartan (30 mg/kg per day)

Outcome

Systemic and tissue renin-angiotensin system (RAS) activity, cardiovascular and renal damage (systolic blood pressure, urinary protein excretion, plasma angiotensin II, urinary angiotensinogen, glomerular injury, and interstitial fibrosis)surrogate

In spontaneously hypertensive rats, salt-induced renal injury is mediated by AT1 receptor activation and can be ameliorated by losartan independent of blood pressure reduction.

Cite This Study

Sušić et al. (2011) studied this question.

synapsesocial.com/papers/6a712117af0c21e93928caec https://doi.org/10.1097/hjh.0b013e3283440683

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Implication

Losartan may confer BP-independent renal protection in salt-loaded hypertensive rats; hypothesis-generating for human CKD but should not change practice.

Salt-induced renal injury in SHRs is mediated by AT1 receptor activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Salt-induced renal injury in SHRs is mediated by AT1 receptor activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider