Key result
Candesartan ameliorated salt-related structural and functional cardiac and renal abnormalities in spontaneously hypertensive rats without reducing arterial pressure.
Why the study?
Does candesartan prevent target organ damage in salt-loaded spontaneously hypertensive rats?
Population
8-week-old spontaneously hypertensive rats (SHRs) on an 8% salt diet for 8 weeks
Comparison
Candesartan 10 mg/kg/day concomitantly with 8%… vs Salt-loaded SHRs without ARB and age- and…
Design
Preclinical
Follow-up
8 weeks
Authors
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AT1 blockade attenuates salt-induced cardiac damage independent of pressure in SHR; leaves open translation to human salt-sensitive hypertension.
Does candesartan prevent target organ damage in salt-loaded spontaneously hypertensive rats?
AT1 receptor antagonism with candesartan ameliorates salt-induced structural and functional cardiac and renal abnormalities in spontaneously hypertensive rats independently of arterial pressure reduction.
Varagić et al. (2007) studied Hypertension and salt-induced target organ damage. Candesartan vs. 8% salt diet alone and standard chow controls was evaluated on Arterial pressure and target organ damage (LV remodeling, myocardial fibrosis, LV diastolic dysfunction). Candesartan ameliorated salt-related structural and functional cardiac and renal abnormalities in spontaneously hypertensive rats without reducing arterial pressure.
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