Key result
Angiotensin receptor blockade with candesartan or losartan completely restored renal function in salt-loaded spontaneously hypertensive rats without decreasing arterial pressure.
Why the study?
Does angiotensin II receptor blockade prevent salt-induced renal injury in spontaneously hypertensive rats?
Population
Male, 8-week-old spontaneously hypertensive rats (SHR) subjected to salt overload (8% salt chow).
Comparison
Angiotensin II receptor blockade using either… vs Two control groups: one receiving regular chow…
Design
Preclinical
Follow-up
8 weeks
Authors
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ARB may attenuate salt-induced renal injury in hypertensive rats; leaves open clinical relevance in human salt-sensitive disease.
Does angiotensin II receptor blockade prevent salt-induced renal injury in spontaneously hypertensive rats?
Angiotensin receptor blockade prevents salt-induced renal damage in hypertensive rats independently of blood pressure reduction, suggesting a direct pathogenic role of the renin-angiotensin system in salt-induced renal injury.
Sušić et al. (2009) studied Hypertension and salt-induced renal injury. Candesartan or losartan vs. Regular chow (control) or 8% salt chow without ARB was evaluated on Mean arterial pressure and indices of renal function (renal blood flow, glomerular filtration rate, urinary protein excretion). Angiotensin receptor blockade with candesartan or losartan completely restored renal function in salt-loaded spontaneously hypertensive rats without decreasing arterial pressure.
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