Key result
Combined blockade of AT(2) and AT((1-7)) receptors significantly increased the blood pressure of losartan-treated salt-depleted spontaneously hypertensive rats by 15 ± 1 mmHg (P < 0.01).
Population
Adult 9-wk-old male conscious salt-depleted spontaneously hypertensive rats (SHR)
Comparison
Intravenous infusion of losartan, PD-123319… vs Vehicle or alternative antagonist combinations
Design
Preclinical
Authors
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Suggests compensatory BP-lowering via non-AT1 receptors during AT1 blockade in rats; leaves open relevance to human hypertension.
Mean Difference: 15
p-value: p=<0.01
In salt-depleted spontaneously hypertensive rats, ANG II and ANG-(1-7) act through non-AT1 receptors to oppose the vasoconstrictor actions of ANG II.
Nakamura et al. (2003) studied Salt-depleted spontaneously hypertensive rats (SHR). Combined blockade of AT(2) and AT((1-7)) receptors (Losartan, PD-123319, [d-Ala(7)]ANG-(1-7)) vs. 5% dextrose in water as vehicle was evaluated on Blood pressure (MD +15 mmHg, p=<0.01). Combined blockade of AT(2) and AT((1-7)) receptors significantly increased the blood pressure of losartan-treated salt-depleted spontaneously hypertensive rats by 15 ± 1 mmHg (P < 0.01).
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