What question did this study set out to answer?

The study aims to determine whether angiotensin-(1-7) can induce a vasodepressor response in conscious spontaneously hypertensive rats during AT1 receptor blockade.

March 15, 2005Hypertension

Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does Angiotensin-(1-7) reduce mean arterial pressure in conscious rats during AT1 receptor blockade?

Population

Conscious spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Comparison

Angiotensin- coadministered with candesartan… vs Saline, candesartan alone, or Ang-(1-7) alone

Design

Preclinical, randomized

Follow-up

5 days

Authors

PWP. WaltersMonash University TGTracey A. GaspariDiscovery Institute RWRobert E. WiddopGeneral Cardiology

Discussion

Member takes

Implication

Does not support clinical use of Ang-(1-7) with AT1 blockade; leaves open whether the AT2-bradykinin-NO pathway translates to human hypertension.

Key Points

The study aims to determine whether angiotensin-(1-7) can induce a vasodepressor response in conscious spontaneously hypertensive rats during AT1 receptor blockade.
Spontaneously hypertensive rats were randomized into various treatment groups including saline, AT1 receptor antagonist, and Ang-(1-7) with or without AT2 receptor antagonist.
Mean arterial pressure and heart rate were measured over a 5-day period.
The study included assessments of the interactions between angiotensin-(1-7) and bradykinin type 2 receptor and NO synthase inhibitors.
Ang-(1-7) combined with AT1 receptor antagonist caused a significant reduction in mean arterial pressure in SHR (exact metrics not specified).
AT2 receptor blockade attenuated the depressor response from the combination of Ang-(1-7) and AT1 receptor antagonist.
Inhibiting bradykinin type 2 receptor or NO synthase abolished the vasodepressor effect of Ang-(1-7) in the presence of candesartan.

Structured PICO

Does Angiotensin-(1-7) reduce mean arterial pressure in conscious rats during AT1 receptor blockade?

Population

Conscious spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Intervention

Angiotensin-(1-7) (5 pmol/min) coadministered with candesartan (0.01 or 0.1 mg/kg IV), with or without AT2 receptor antagonist PD123319, A-779, HOE 140, or L-NAME

Comparator

Saline, candesartan alone, or Ang-(1-7) alone

Outcome

Mean arterial pressure (MAP) and heart ratesurrogate

Ang-(1-7) exerts a vasodepressor effect during AT1 receptor blockade via activation of AT2 receptors and the bradykinin-NO cascade.

Cite This Study

Walters et al. (2005) studied this question.

synapsesocial.com/papers/6a6fb6516ceb2bbd16dfb7a0 https://doi.org/10.1161/01.hyp.0000160325.59323.b8

View Full Paper

Ask AI

Bookmark

Implication

Does not support clinical use of Ang-(1-7) with AT1 blockade; leaves open whether the AT2-bradykinin-NO pathway translates to human hypertension.

Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider