Population
Conscious adult (~17 weeks) and aged (~19 months) normotensive Wistar-Kyoto (WKY) rats
Comparison
Drug combinations administered over a 4-day… vs Different drug combinations within the protocol
Design
Preclinical, randomised fashion
Follow-up
4-day protocol
Authors
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Aging shifts Ang(1-7) vasodepression from AT2R-only to dual receptors in rats; leaves open translation to age-specific human hypertension therapies.
Aging alters the mechanism of Ang (1-7)-mediated vasodepression, shifting from exclusive AT2R dependence in adults to involvement of both AT2R and MasR in aged rats.
Bosnyak et al. (2011) studied this question.
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