Key result
In rats with altered nephrogenesis, candesartan reduced blood pressure more in males than females (P<0.05), suggesting oxidative stress mediates Ang II's role in maintaining hypertension.
Why the study?
Does Ang II mediate hypertension and renal changes in rats with altered nephrogenesis, and are these effects age- and sex-dependent?
Population
Male and female rats treated with an AT1 receptor antagonist during the nephrogenic period, evaluated at 3…
Design
Preclinical
Follow-up
Evaluated at 3 and 10 months of age
Authors
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Cautious interpretation required from this rat model; leaves open whether oxidative stress mediates sex-specific Ang II effects in human hypertension.
Does Ang II mediate hypertension and renal changes in rats with altered nephrogenesis, and are these effects age- and sex-dependent?
p-value: p=<0.05
In a rat model of altered nephrogenesis, Ang II maintains hypertension and renal changes via oxidative stress in an age- and sex-dependent manner.
Salazar et al. (2012) studied Hypertension and renal changes with altered nephrogenesis. AT1 receptor antagonist during nephrogenic period (ARAnp) was evaluated on Blood pressure and renal hemodynamic changes (p=<0.05). In rats with altered nephrogenesis, candesartan reduced blood pressure more in males than females (P<0.05), suggesting oxidative stress mediates Ang II's role in maintaining hypertension.
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