Population
3- to 4- and 10- to 11-month-old male and female rats treated with vehicle or an AT receptor antagonist…
Comparison
Candesartan (7 mg·kg·day for 3 days), tempol (18… vs Vehicle treatment or baseline
Design
Preclinical
Authors
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Sex differences in ARB response may emerge with aging in this model; leaves open translation to human hypertension and need for prospective study.
Adverse events during the nephrogenic period induce an ANG II-dependent increment in arterial pressure that is aggravated only in males during aging, driven by oxidative stress rather than increased AT(1) receptors.
Reverte et al. (2012) studied this question.
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