Population
Male and female rats
Comparison
2-week subcutaneous infusion of low-dose or… vs Vehicle infusion
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not support clinical translation; hypothesis-generating for sex-specific AT2R effects in hypertension models.
In female rats, low-dose angiotensin II paradoxically decreases arterial pressure via enhanced AT2R and ACE2 mechanisms, highlighting sex-specific differences in the regulation of the renin-angiotensin system.
Sampson et al. (2008) studied this question.
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