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February 1, 1998Hypertension229 citationsOpen Access

Vasodepressor Actions of Angiotensin-(1–7) Unmasked During Combined Treatment With Lisinopril and Losartan

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Why the study?

Does Ang-(1-7) mediate the vasodepressor effects of combined ACE inhibitor and AT1 receptor blocker therapy in spontaneously hypertensive rats?

Population

21 male spontaneously hypertensive rats treated with oral lisinopril and losartan for 8 days

Comparison

15-minute infusion of a specific monoclonal Ang… vs 15-minute infusion of mouse immunoglobulin G1

Design

Preclinical

Follow-up

15-minute infusion

Authors

SIShridhar N. IyerMCMark C. ChappellDADavid B. Averill

Discussion

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Overview

May support Ang-(1-7) mediation of combined ACE inhibitor/ARB effects in rat hypertension; leaves open clinical relevance in humans.

Structured PICO

Does Ang-(1-7) mediate the vasodepressor effects of combined ACE inhibitor and AT1 receptor blocker therapy in spontaneously hypertensive rats?

P
Population
21 male spontaneously hypertensive rats (SHR) treated with oral lisinopril (20 mg/kg) and losartan (10 mg/kg) for 8 days
I
Intervention
15-minute infusion of a specific monoclonal Ang-(1-7) antibody
C
Comparator
15-minute infusion of mouse immunoglobulin G1
O
Outcome
Mean arterial pressure and heart ratesurrogate

Ang-(1-7) plays an important role in mediating the vasodilator effects caused by combined inhibition of ACE and AT1 receptors, likely via a non-AT1/AT2 receptor.

Cite This Study

Iyer et al. (1998) studied this question.

synapsesocial.com/papers/6a1c7b0d0e2acd31eb2fccd6https://doi.org/10.1161/01.hyp.31.2.699
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