What does this research mean for the field?

Endogenous Angiotensin-(1-7) functions as a vasodilator hormone that actively contributes to the antihypertensive effects of combined renin-angiotensin system blockade. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether endogenous angiotensin-(1-7) contributes to the blood pressure-lowering effects of combined lisinopril and losartan administration in spontaneously hypertensive rats.

January 1, 1998Hypertension

Angiotensin-(1–7) Contributes to the Antihypertensive Effects of Blockade of the Renin-Angiotensin System

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Why the study?

Does inhibition of Ang-(1-7) synthesis with neprilysin inhibitors reverse the antihypertensive effects of combined lisinopril and losartan in spontaneously hypertensive rats?

Key Points

To determine whether endogenous angiotensin-(1-7) contributes to the blood pressure-lowering effects of combined lisinopril and losartan administration in spontaneously hypertensive rats.
Spontaneously hypertensive rats were treated for 9 days with lisinopril and losartan to normalize blood pressure.
Rats were administered intravenous neprilysin inhibitors (CGS 24592 or SCH 39370, each at 30 mg/kg) to block Ang-(1-7) synthesis, alone or following pretreatment with [Sar1,Thr8]-Ang II, BQ123, or HOE 140.
CGS 24592 infusion increased mean arterial pressure throughout the infusion period and for 20 minutes post-infusion, coinciding with a 62% decrease in plasma Ang-(1-7) and unchanged plasma Ang II.
SCH 39370 elicited an increase in mean blood pressure, and pretreatment with [Sar1,Thr8]-Ang II abolished the pressor responses induced by both neprilysin inhibitors.
Pretreatment with the endothelin A antagonist BQ123 or kinin B2 antagonist HOE 140 did not alter basal blood pressure or the pressor and heart rate responses to neprilysin inhibition.

Structured PICO

Does inhibition of Ang-(1-7) synthesis with neprilysin inhibitors reverse the antihypertensive effects of combined lisinopril and losartan in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats in which blood pressure was normalized by 9 days of therapy with lisinopril and losartan

Intervention

Intravenous administration of neprilysin inhibitors (CGS 24592 30 mg/kg or SCH 39370 30 mg/kg)

Comparator

null

Outcome

Mean arterial pressuresurrogate

Endogenous Ang-(1-7) functions as a vasodilator hormone that contributes to the antihypertensive effects of combined ACE inhibitor and AT1 receptor antagonist therapy in genetic hypertension.

Discussion

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Implication

Supports Ang-(1-7) contribution to ACEI/ARB effects in genetic hypertension; leaves open translation to neprilysin inhibitor use in patients.

Cite This Study

Iyer et al. (1998) studied this question.

synapsesocial.com/papers/6a1c7b0d0e2acd31eb2fccd7 https://doi.org/10.1161/01.hyp.31.1.356

Topics

Hypertension management

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Implication

Supports Ang-(1-7) contribution to ACEI/ARB effects in genetic hypertension; leaves open translation to neprilysin inhibitor use in patients.

Angiotensin-(1–7) Contributes to the Antihypertensive Effects of Blockade of the Renin-Angiotensin System

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Angiotensin-(1–7) Contributes to the Antihypertensive Effects of Blockade of the Renin-Angiotensin System

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider