Key result
The addition of the Ang (1-7) antagonist A779 to losartan attenuated the drop in mean arterial pressure compared to losartan alone (decrease of 21+2 mmHg vs 27+1 mmHg).
Why the study?
Does Ang (1-7) antagonism with A779 attenuate the hypotensive effects of losartan in normal rats?
Population
Sprague-Dawley rats on a normal (0.4%) NaCl diet, n=19
Comparison
Losartan and the Ang antagonist, A779 for 10 days vs Losartan (10 mg/kg/day) alone for 10 days
Design
Preclinical
Follow-up
10 days
Authors
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Supports partial mediation of losartan’s hypotensive effects by Ang(1-7) in normotensive rats; hypothesis-generating and should not yet inform clinical practice.
Does Ang (1-7) antagonism with A779 attenuate the hypotensive effects of losartan in normal rats?
Absolute Event Rate: 21% vs 27%
The chronic hypotensive effects of losartan in normal rats are partially mediated by the actions of Ang (1-7).
Collister et al. (2003) studied Normotensive (n=19). A779 (Ang (1-7) antagonist) and losartan vs. Losartan (10 mg/kg/day) alone was evaluated on Decrease in mean arterial pressure by day 7. The addition of the Ang (1-7) antagonist A779 to losartan attenuated the drop in mean arterial pressure compared to losartan alone (decrease of 21+2 mmHg vs 27+1 mmHg).
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