Key result
Co-administration of the AT2 receptor antagonist PD123319 with losartan decreased arterial pressure more than losartan alone (-31 vs -22 mm Hg, p < 0.05) in normotensive rats at 10 days.
Why the study?
Does AT2 receptor blockade with PD123319 alter the hypotensive effects of losartan in normotensive, salt-replete rats?
Population
Normotensive, salt-replete rats
Comparison
PD123319 in conjunction with losartan infused… vs Losartan alone (10 mg/kg/day)
Design
Preclinical
Follow-up
10 days
Authors
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AT2 blockade may augment losartan hypotensive effects in normotensive rats; leaves open translation to clinical hypertension.
Does AT2 receptor blockade with PD123319 alter the hypotensive effects of losartan in normotensive, salt-replete rats?
Absolute Event Rate: -31% vs -22%
p-value: p=< 0.05
The chronic hypotensive effects of losartan are not dependent on the actions of angiotensin II at AT2 receptors in normotensive, salt-replete rats.
Collister et al. (2002) studied Normotensive, salt-replete. Losartan and PD123319 vs. Losartan alone (10 mg/kg/day) was evaluated on Decrease in arterial pressure at day 10 (p=< 0.05). Co-administration of the AT2 receptor antagonist PD123319 with losartan decreased arterial pressure more than losartan alone (-31 vs -22 mm Hg, p < 0.05) in normotensive rats at 10 days.
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