Why the study?
Does losartan reduce thrombus weight via AT2-receptor stimulation in renal hypertensive rats?
Population
Renal hypertensive rats with venous thrombosis induced by a two-hour ligation of the vena cava
Comparison
Losartan with or without PD123319 vs PD123319 alone or implied untreated control
Design
Preclinical
Follow-up
2 hours
Authors
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May support AT2-dependent antithrombotic effects of losartan in hypertensive rats; leaves open clinical translation.
Does losartan reduce thrombus weight via AT2-receptor stimulation in renal hypertensive rats?
The antithrombotic effect of losartan in renal hypertensive rats is dependent on AT2-receptor stimulation.
Chabielska et al. (2000) studied this question.
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