Acute renal excretory actions of losartan in spontaneously hypertensive rats

Spontaneously hypertensive rats

Acute intravenous losartan (1 mg/kg) co-administered with AT2 receptor antagonist PD 123319 (10 mg/kg), bradykinin B2 receptor antagonist Hoe 140 (30 µg/kg), cyclo-oxygenase inhibitor meclofenamate (5 mg/kg), or nitric oxide synthesis inhibitor NG-monomethyl-L-arginine (1 µg/kg per min)

Acute intravenous losartan alone

Mean arterial pressure and renal excretory function (glomerular filtration rate, urine flow, and sodium excretion rate)surrogate