Why the study?
Does ANG-(1-7) prevent development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME?
Does ANG-(1-7) prevent development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME?
In a rat model of reduced nitric oxide availability, ANG-(1-7) attenuates the development of severe hypertension and end-organ damage, providing evidence for its role in the protective effects of ACE inhibition.
No takes yet. Share an insight, caveat, or question.
Offers mechanistic support for ANG-(1-7) in ACE inhibitor effects; leaves open translation to clinical hypertension.
Benter et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: