August 1, 1993Journal of Hypertension
Dietary salt excess unmasks blunted aldosterone suppression and sodium retention in the stroke-prone phenotype of the spontaneously hypertensive rat
Population
6-week-old stroke-prone spontaneously hypertensive rats, age-matched spontaneously hypertensive rats, and…
Comparison
High-salt diet (4% NaCl) for 1 week vs Comparison of responses between the three rat…
Design
Preclinical
Follow-up
1 week
Authors
Discussion
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Implication
Impaired natriuresis in SHRSP may reflect salt sensitivity; leaves open translation to human hypertension mechanisms.
Structured PICO
P
Population
6-week-old stroke-prone spontaneously hypertensive rats (SHRSP, n=84), age-matched spontaneously hypertensive rats (SHR, n=73), and normotensive Wistar-Kyoto (WKY) rats (n=52)
I
Intervention
High-salt diet (4% NaCl) for 1 week
C
Comparator
Comparison of responses between the three rat strains (SHRSP vs SHR and WKY)
O
Outcome
Sodium balance and hormonal parameters (urinary sodium excretion, plasma renin activity, plasma aldosterone concentrations)surrogate
Young stroke-prone spontaneously hypertensive rats exhibit defective sodium excretion and blunted aldosterone suppression in response to high salt intake, providing mechanistic insight into their susceptibility to vascular injury.
Cite This Study
Volpe et al. (1993) studied this question.