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March 1, 2001Journal of Hypertension

Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats

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Why the study?

Does high salt intake increase cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats?

Population

Four-week-old stroke-prone spontaneously hypertensive rats (SHRSP)

Comparison

0.9% NaCl solution for hydration for 4 weeks in… vs Tap water for hydration for 4 weeks in addition…

Design

Preclinical

Follow-up

4 weeks

Authors

YTYoshiyu TakedaTYTakashi YonedaMDMasashi Demura

Discussion

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Overview

Hypothesis-generating for salt-aldosterone links in hypertensive models; leaves open relevance to human disease.

Structured PICO

Does high salt intake increase cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats?

P
Population
Four-week-old stroke-prone spontaneously hypertensive rats (SHRSP)
I
Intervention
0.9% NaCl solution for hydration for 4 weeks in addition to a normal salt diet
C
Comparator
Tap water for hydration for 4 weeks in addition to a normal salt diet
O
Outcome
Cardiovascular aldosterone synthesis (aldosterone production, expression of CYP11B2 mRNA and AT1R mRNA in mesenteric arteries and hearts)surrogate

High salt intake increases local cardiovascular aldosterone production and AT1R expression in stroke-prone spontaneously hypertensive rats, potentially contributing to malignant hypertension.

Cite This Study

Takeda et al. (2001) studied this question.

synapsesocial.com/papers/6a72f920360ad7fbc59a2e4chttps://doi.org/10.1097/00004872-200103001-00017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Production of Aldosterone in Isolated Rat Blood Vessels1995 · 168 citations
  2. 2Human Vascular Renin-Angiotensin System and Its Functional Changes in Relation to Different Sodium Intakes1998 · 84 citations
  3. 3Local Angiotensin II Generation in the Rat Heart1998 · 98 citations
  4. 4Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions1992 · 3,758 citations
  5. 5Myocardial Production of Aldosterone and Corticosterone in the Rat1998 · 448 citations