Why the study?
Does salt-loading and the renin-angiotensin system participate in malignant hypertension in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHR)
Comparison
1% NaCl as drinking water, exogenous angiotensin… vs Rats on water
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for renin-angiotensin activation in malignant hypertension models.
Does salt-loading and the renin-angiotensin system participate in malignant hypertension in stroke-prone spontaneously hypertensive rats?
The activation of the renin-angiotensin system participates in the development of malignant hypertension and stroke in salt-loaded stroke-prone spontaneously hypertensive rats.
Shibota et al. (1979) studied this question.
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