Why the study?
Is plasma renin a major risk factor for the development of cardiovascular complications in spontaneously hypertensive rats?
Population
Stroke-prone and stroke-resistant substrains of the spontaneously hypertensive rat (SHR)
Design
Preclinical
Authors
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Challenges renin causality in hypertensive complications; hypothesis-generating for human studies on reverse causality.
Is plasma renin a major risk factor for the development of cardiovascular complications in spontaneously hypertensive rats?
High plasma renin levels in advanced hypertension appear to be a consequence of severe vascular damage rather than a primary risk factor for cardiovascular complications in a rat model.
Matsunaga et al. (1976) studied this question.
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