Population
Spontaneously hypertensive rats (SHR) and genetic normotensive control Wistar-Kyoto (WKY) rats
Design
Review
Authors
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Findings in SHR models do not inform human hypertension management; leaves open whether vascular rarefaction precedes essential hypertension.
This review highlights that structural and excitation-contraction abnormalities in resistance vessels contribute to elevated blood pressure in spontaneously hypertensive rats and may precede the onset of hypertension.
Michael J. Mulvany (2008) studied this question.
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