Key result
Spontaneously hypertensive rats exhibited significantly raised flow resistance even during maximal dilatation (p<0.001) and a steeper resistance response to noradrenaline (p<0.001) compared to controls.
Population
Spontaneously hypertensive rats (SHR) and matched normotensive control rats (NCR) (15 paired experiments)
Comparison
Graded noradrenaline infusions during constant… vs Normotensive control rats (NCR)
Design
Preclinical
Authors
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Supports structural vascular changes in SHR; leaves open translation to human hypertension management.
p-value: p=<0.001
Structural changes, specifically increased contractile wall mass encroaching upon the lumen, can largely account for the raised resistance and increased vascular reactivity in spontaneously hypertensive rats.
Folkow et al. (1970) studied Hypertension (animal model) (n=30). Spontaneous hypertension vs. Normotensive control was evaluated on Flow resistance and vascular reactivity to graded noradrenaline infusions (p=<0.001). Spontaneously hypertensive rats exhibited significantly raised flow resistance even during maximal dilatation (p<0.001) and a steeper resistance response to noradrenaline (p<0.001) compared to controls.
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