January 1, 1986Clinical and Experimental Hypertension

Brain Renin Angiotensin System Contributes to the Salt-Induced Enhancement of Hypertension in Shr

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Population

5-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats

Comparison

1% NaCl solution as drinking water for 7 weeks vs Plain tap water

Design

Preclinical

Follow-up

7 weeks

Authors

YTYutaka TakataKyushu Dental University YYYoshiaki YamashitaMie University Hospital STShuichi TakishitaKagoshima University

Discussion

Member takes

Implication

Supports brain RAS role in salt-exacerbated SHR hypertension; leaves open clinical translation and therapeutic targeting in humans.

Structured PICO

Population

5-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats

Intervention

1% NaCl solution as drinking water for 7 weeks

Comparator

Plain tap water

Outcome

Blood pressure response to intracerebroventricular (ICV) captopril and angiotensin IIsurrogate

Long-term salt overload enhances the activity of the brain renin-angiotensin system, which may be responsible for the exaggerated development of hypertension in spontaneously hypertensive rats.

Cite This Study

Takata et al. (1986) studied this question.

synapsesocial.com/papers/6a8c1917d5d4290f64f49b3e https://doi.org/10.3109/10641968609045479

Topics

Hypertension management

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